Critical Care A Day
Thursday January 27, 2022
Thursday January 27, 2022
Q: Which of the following group of drugs has the best anti-proteinuria effect?
A) calcium channel blockers
B) beta blockers
C) diuretics
D) alpha-1-blockers
E) methyldopa
Answer: A
Although ACE inhibitors and Angiotensin II receptor blockers (ARBs) are known as anti-proteinuria agents and are used as a standard in diabetic patients. In addition, non-dihydropyridine calcium channel blockers (diltiazem, verapamil) has a good antiproteinuric effect.
Beta-blockers, diuretics, and alpha-1-blockers have some antiproteinuric effects but methyldopa has little effect on protein excretion.
#pharmacology
References:
1. Bakris GL, Weir MR, Secic M, et al. Differential effects of calcium antagonist subclasses on markers of nephropathy progression. Kidney Int 2004; 65:1991.
2. Ruggenenti P, Perna A, Benini R, Remuzzi G. Effects of dihydropyridine calcium channel blockers, angiotensin-converting enzyme inhibition, and blood pressure control on chronic, nondiabetic nephropathies. Gruppo Italiano di Studi Epidemiologici in Nefrologia (GISEN). J Am Soc Nephrol 1998; 9:2096.